CaMKII和心力衰竭(英文)-课件幻灯演示幻灯片.pptVIP

CaMKII and Heart Failure Yanggan Wang, MD, PhD 5 million patients with Heart failure in US. 0.5 million new HF patients and 0.25 million deaths annually. The precise mechanisms underlying the contractile and electrical abnormalities of hypertrophy and HF remains elusive. Ineffective therapies. INTRODUCTION Natriuretic peptide Receptors Neural hormonal signals Biomechanical stress PKC PKA Guanylyl Cyclase Adenylyl cyclase Stretch sensor MAPK Calcineurin CaMKII Transcription factors NFAT, MEF2, GATA4 Fetal gene activation and cardiac remodeling Gαq TRPC TRPC SAC Ca2+ (fo