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Ezetimibe Reduces Blood Sitosterol in Sitosterolemic Humans Lutjohann D, et al. Int J Clin Pract 2008:62:1499 Campesterol 0 50 100 150 Day 0 Day 15 Day 30 % of the value on day 0 KO/Zetia Sitosterol 0 50 100 150 Day 0 Day 15 Day 30 KO/Chow Ezetimibe Reduces Plasma Plant Sterol Levels in the Absence of ABCG5/8 Genetic Ablation of NPC1L1 Prevents Sitosterolemia in Mice Lacking ABCG5/G8 Tang W, et al. JLR 2008 Other Potential Beneficial Effects of Ezetimibe 1. On fatty liver ? WT-T 3.4±0.4a 2.3±0.4a 12.3±0.7a 241.8±29.1b L1KO-V 4.1±0.3a 3.6