心衰中的炎症-课件(英文）演示文稿.pptVIP

1 Inflammation in heart failure Liao Yu-Hua Institute of Cardiology Union Hospital Huazhong University of Science and Technology, Wuhan China 2 Cognitive process of pathophysiology and therapy in haert failure 3 Inflammation and Heart failure Interaction between neuroendocrine and cytokines in heart failure therapy between inflammation and heart failure 4 β-adrenergic stimulation induces proinflammatory cytokine expression in myocardium *P0.01, **P0.0001 vs saline-treated animals. Murray et al. Circulation. 2000;101:2338-2341. In control myocardium, TNF-a,IL-1b and IL-6 were not detected. Isoproterenol infusion significantly increased expression of all 3 cytokines, indicating that chronic β-adrenergic stimulation was associated with proinflammatory cytokine expression. 5 Causal relationship between Ang II and TGF-β1 in cardiac hypertrophy Schultz JEJ, et al. J Clin Invest 2002;109:787– 96 The lack of the TGFβ1 gene fully prevented the development of cardiac hypertrophy induced by subpressor doses of Ang II that was observed in wild type mice Ang II-induced cardiac hypertrophy is mediated by TGF-β1 6 Evidence for a connection between Ang II and TGF-β1 in cardiac tissue Stephan Rosenkranz.Cardiovascular Research 2004; 63:423– 432 Some studies indicate that Ang II and TGF-β1 act in an auto-/paracrine manner, and suggest cross-talk between the various myocardial cell types and compartments 7 Angiotensin II-induced myocardial TNF biosynthesis in the adult heart TNF mRNA expression Kalra D, et al. Circulation 2002; 105:2198– 205. Treatment with Ang II resulted in a rapid increase in TNF mRNA synthesis in isolated buffer perfused hearts 8 Angiotensin II induced activation of NF-ĸB Kalra D, et al. Circulation 2002; 105:2198– 205. Stimulation with Ang II lead to a rapid increase in NF-κB binding activity in isolated buffer perfused hearts, the finding suggest a possible pathway in Ang II mediated TNF biosynthesis 9 Cross-regulation between the renin-angiotensin