[工程科技]Lec3数据库查询和检索.pptVIP

Entrez 美国国家生物技术信息中心 (NCBI) 所提供的在线资源检索器。该资源将GenBank序列与其原始文献出处链接在一起。 Entrez 是由NCBI主持的一个数据库检索系统，它包括核酸，蛋白以及Medline文摘数据库，在这三个数据库中建立了非常完善的联系。因此，可以从一个DNA序列查询到蛋白产物以及相关文献，而且，每个条目均有一个类邻(neighboring)信息，给出与查询条目接近的信息。 Entrez a client-server system for retrieval of information related to molecular biology can be used via web page via embedded client in other software (e.g., MacVector) provided by National Center for Biotechnology Information (NCBI), part of the National Library of Medicine (NIH) Entrez 数据库 Entrez中的数据库包括： Entrez中核酸数据库为：GenBank, EMBL, DDBJ 蛋白质数据库为：Swiss-Prot, PIR, PFR, PDB PubMed 基因组和染色体图谱资料 Entrez Databases PubMed: The biomedical literature PUBMED database contains Medline abstracts as well as links to full text articles on sites maintained by journal publishers Nucleotide sequence database (Genbank) Protein sequence database Structure: three-dimensional macromolecular structures Genome: complete genome assemblies PopSet: population study data sets Entrez Databases OMIM: Online Mendelian Inheritance in Man Taxonomy: organisms in GenBank Books: online books ProbeSet: Gene Expression Omnibus (GEO) 3D Domains: domains from Entrez Structure Entrez essentials Semi-automated entry of information into databases Critical to usefulness is the links between databases Entrez literature searching can find papers on a given subject can find papers on a specific gene can find papers related to a given paper can switch between literature and sequence databases Pubmed has links to publishers’ websites to view full text of articles Pubmed Central has free full text copies Entrez sequence searching can find sequences for a given gene or protein can download copy of sequence Example Entrez Session Goal: Find literature and sequences for cystic fibrosis genes（胆囊纤维基因） Use OMIM with Keyword searching. Switch to Protein database to see sequence. Change to GenPept format to