心脑血管药理食管癌放疗增敏reversalmdr.pptVIP

Reversal of Tumor Multidrug Resistance Fu LiWu, Pan Qichao (Cancer Center, Sun Yat-Sen University, Guangzhou 510060, China) Main treatment for cancer Surgery Radiotherapy Chemotherapy Immunotherapy and Others The Causes of failure Chemotherapy Toxicity Resistance Resistance to chemotherapeutic agents remains a major obstacle to efficient cancer therapy The causes are very complex. Multidrug resistance (MDR) MDR induced by several causes Cellular membrane P-gp (P170) MRP 1(P190) c-Maot (P190) LRP (P110) BCRP (P70) Cellular plasma IAPs PKC Topo II GSH, GST MT Bcl-2, Bcl-xL, Bcr-Abl P53 P-g