Long term type diabetes impairs decidualization and…长期糖尿病会损害蜕膜化和.pdfVIP

Placenta 34 (2013) 1128e1135 Contents lists available at ScienceDirect Placenta journal homepage: www.elsevi /locate/placenta Long-term type 1 diabetes impairs decidualization and extracellular matrix remodeling during early embryonic development in miceq R.R. Favaro a, *, R.M. Salgado a, A.C. Covarrubias a, F. Bruni b, C. Lima b, Z.B. Fortes c, T.M. Zorn a a Laboratory of Reproductive and Extracellular Matrix Biology, Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil b Special Laboratory of Applied Toxinology (CAT/CEPID), Butantan Institute, São Paulo, Brazil c Laboratory of Diabetes and Hypertension, Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil a r t i c l e i n f o a b s t r a c t Article history: Introduction: Endometrial decidualization and associated extracellular matrix (ECM) remodeling are Accepted 18 September 2013 critical events to the establishment of the maternalefetal interface and successful pregnancy. Here, we investigated the impact of type 1 diabetes on these processes during early embryonic development, in On occasion of the 30th anniversary of the Laboratory of Reproductive and Extracel- order to contribute to the understanding of the maternal factors associated to diabetic embryopathies. lular Matrix Biology we dedicate this article Methods: Alloxan-induced diabetic Swiss female mice were bred after different periods o