Tissue Destructive Macrophages in Giant Cell Arteritis组织破坏性巨噬细胞在巨细胞动脉炎中的作用.pdfVIP

Tissue-Destructive Macrophages in Giant Cell Arteritis Heike L. Rittner, Markus Kaiser, Alexander Brack, Luke I. Szweda, Jo¨rg J. Goronzy, Cornelia M. Weyand Abstract—Giant cell arteritis (GCA) is an inflammatory vasculopathy in which T cells and macrophages infiltrate the wall of medium and large arteries. Clinical consequences such as blindness and stroke are related to arterial occlusion. Formation of aortic aneurysms may result from necrosis of smooth muscle cells and fragmentation