Wegenerautoantigeninducesmaturationofdendriticcellsandlicenses….pdfVIP

From by guest on February 26, 2016. For personal use only. IMMUNOBIOLOGY Wegener autoantigen induces maturation of dendritic cells and licenses them for Th1 priming via the protease-activated receptor-2 pathway Elena Csernok, MaiXing Ai, Wolfgang L. Gross, Daniel Wicklein, Arnd Petersen, Buko Lindner, Peter Lamprecht, Julia U. Holle, and Bernhard Hellmich Autoantibodies to proteinase 3 (PR3) are treated DCs express high levels of CD83, directed against the protease-activated involved in the pathogenesis of autoim- a DC-restricted marke