(精编)【高血压英文教学精品课件】 Hypertension and the Kidney.pptVIP

Hypertension and the Kidney;Hypertension and the Kidney;Role of Kidney in Hypertension;Pressure-natriuresis(1);Pressure-natriuresis(2)(Medullary Blood Flow);Pressure-natriuresis(3);Pressure-natriuresis(4);Fig. 4. Steady-state relationships between arterial pressure and urinary sodium ecreation and sodium intake for normal kidney and four types of renal dysfunction that cause hypertension: decreased kidney mass, increased reabsorption in distal and collecting tubules, reduction in glomerular capillary filtration coefficient(Kf), and increased preglomerular resistance.;Congenital Oligonephropathy;Renal Transplantation Studies;Fig. 5. Effects of renal cross-transplantations on systolic blood pressure in five different animal medels of genetic hypertension. A. Normotensive recipients received a kidney from hypertensive donors. B. Hypertensive recipients received a kidney from normotensive donors. Symbols are:(?) Dahl salt-senstive hypertensive rats; (?) Milan hypetensive rats and Milan normotensive rats; (?) Prague hypertensive rats and Prague normotensive rats; ?Normotensive Wistar Kyoto rats (donors), spontaneously hypertensive rats and F1 hybrids(recipients) bred from the first two strains; (?) normotensive Wistar-Kyoto rats(donors), stroke-prone spontaneously hypertensive rats (donors) and F1 hybrids(recipients) bred from the first two strain.;Fig. 6. Blood pressure in human renal graft recipients at one year after transplantation. Based on indirect evidence, donors were assumed to have been normotensive(?) or hypertensive(?). The differences in blood pressure between recipients of a kidney from normotensive and hypertensive donor occurred despite more vigorous antihypertensive treatment in the latter.;Salt and Hypertension(1);Fig. 7. Autoregulation of renal plasma flow and glomerular filtration rate. Note afferent arteriolar resistance(RA) is regulated by boyh myogenic response and tubuloglomerular feedback and angiotensin II(AngII)