(精编)An update from the JSM 2006 - Seattle教学课件.pptVIP

Apologize for over-emphasizing my own work; the spirit is to present to you a series of successful case studies using a particular tool – hazard spline regression – that you might also find useful. Testing what is ”too much”… The two tests can be written: H01: μT - μR ≤ -Δ versus H11: μT - μR ≥ -Δ And then… H02: μT - μR ≥ Δ versus H12: μT - μR ≤ Δ Testing what is ”too much”… The testing parameter Δ was chosen by the FDA to be Δ=log(1.25) Both of the two tests are carried out with a 5% level of significance Thus, there is a maximum 5% chance of declaring two products bioequivalent wh