物理有机化学浙江大学2010年第2章、结构与活性.ppt

Considering the present mechanistic studies on the stoichiometric N arylation of the Cu(I) amidate, a well-defined pathway for aryl iodide activation cannot be resolved. Comparing the activation parameters in addition to the ρ-value (ρ= + 0.48) to those obtained from the oxidative addition of Pd(0) with aryl iodides suggests that the Cu(I) amidate-mediated aryl iodide activation does not involve a rate-determining oxidative addition process involving a Cu(III)/Cu(I) couple. For example, a ρ-value of 2.3 and an enthalpy of activation (ΔH?) of 18.4 kcal mol-1 were obtained for the oxidative add