妇产科学精品教学(重庆医科大学)11endometrial cancer1学时5月5日.pptVIP

妇产科学精品教学(重庆医科大学)11endometrial cancer1学时5月5日.ppt

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Endometrial carcinoma Chang Shufang The Second Affiliated Hospital of Chongqing Medical University New words Paraaortic LN腹主动脉旁淋巴结 fractional curettage分段刮宫 biopsy活组织检查 Papanicolaou smear hysteroscopy宫腔镜检查 Cachexia 恶病质 external OS 子宫外口 Senile vaginitis 老年性阴道炎 Contraindications禁忌症 radical hysterectomy and bilateral adnexectomy根治性子宫切除术加双附件切除 Pyometra 子宫积脓 New words Adriamycin阿霉素 cisplatin顺铂 Carboplatin卡铂 Paclitaxel紫杉醇 cyclo-phosphamide环磷酰胺 megesterol acetate 醋酸甲地孕酮 Tamoxifen 他莫昔芬 INTRODUCTION Endometrial cancer is one of the three main malignant tumors Accounts for about 7% in female carcinoma 20~30% in female reproductive system carcinoma Peak incident age is 58~61 Morbility rises in recent years etiology Excessive estrogen stimulation Obesity Nulliparity Late menopause Unopposed estrogen stimulation:ERT Diabetes mellitus etiology over hyperplasia of endometrium(Type1) hereditary factor:20% has family history Family history or personal history of colon,ovarian or breast cancer Fibroid is associated in about 30% fer cent cases Endometrial hyperplasia precedes carcinma in about 25% cases. pathology Gross Diffuse :the spread is through the endometrium.the myometrium is commonly invaded;may invade to reach the serosal coat. Localised:the usual site is on the fundus.it is either sessile or pedunculated.myometrial invovement is late. Histopathology Endometrioid AdenoCA(80%)adenocarcinoma G1 adenocarcinoma G2 Adenocarcinoma with squamous differention(adenoacanthoma) Adenosquamous adenocarcinoma Mucinous CA Mucinous carcinoma... Papillary Serous AdenoCA (UPSC):1-9% Clear -Cell AdenoCA Clear cell carcinoma ... Squamous-Cell carcinoma Undifferentiated carcinoma Mixed type( adenosquamous carcinoma) Metastatic carcinoma. Route of metastasis Direct adjacent extension Extend by lymphatics metastasis:the chief metastatic path. Blood vessel path---- rarely Focal point review Path

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