Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revea.大脑功能和结构之间复杂的相互作用在APP转基因小鼠大脑淀粉样精品.pdfVIP

NeuroImage 134 (2016) 1–11 Contents lists available at ScienceDirect NeuroImage j ournal homepage: www.el /l oca te/ yni mg Complex interplay between brain function and structure during cerebral amyloidosis in APP transgenic mouse strains revealed by multi-parametric MRI comparison Joanes Grandjean a, Rebecca Derungs b,c, Luka Kulic b,c, Tobias Welt b,c, Mark Henkelman d,e, Roger M. Nitsch b,c, Markus Rudin a,b,f,⁎ a Institute for Biomedical Engineering, University and ETH Zürich, Zürich, Switzerland b Center for Neuroscience Research, University and ETH Zürich, Zürich, Switzerland c Division of Psychiatry Research, University of Zürich, Zürich, Switzerland d Mouse Imaging Centre, Hospital for Sick Children, Toronto, Canada e Department of Medical Biophysics, University of Toronto, Toronto, Canada f Institute of Pharmacology and Toxicology, University of Zürich, Zürich, Switzerland a r t i c l e i n f o a b s t r a c t Article history: Alzheimers disease is a fatal neurodegenerative disorder affecting the aging population. Neuroimaging methods, Received 23 November 2015 in particular magnetic resonance imaging (MRI), have helped reveal alterations in the brain structure, metabo- Accepted 17 March 2016 lism, and function of patients and in groups at risk of developing AD, yet the nature of these alterations is poorly Available online 24 March 2016 understood. Neuroimaging in mice is attractive for investigating mechanisms underlying functional and structur-