In Vivo Methods to Study Uptake of Nanoparticles into the Brain（研究纳米粒子吸收入脑的体内方法）.pdfVIP

Pharm Res (2011) 28:456–471 DOI 10.1007/s11095-010-0291-7 EXPERT REVIEW In Vivo Methods to Study Uptake of Nanoparticles into the Brain Inge van Rooy Serpil Cakir-Tascioglu Wim E. Hennink Gert Storm Raymond M. Schiffelers Enrico Mastrobattista Received: 30 June 2010 /Accepted: 20 September 2010 /Published online: 7 October 2010 # The Author(s) 2010. This article is published with open access at S ABSTRACT Several in vivo techniques have been devel- INTRODUCTION oped to study and measure the uptake of CNS compounds into the brain. With these techn