6 信号转导与肿瘤陶永光.pptVIP

* * * Figure 1?|?TGF-beta targets and its actions in mature tissues. ? Transforming growth factor-beta (TGF-beta ) helps maintain tissue homeostasis by controlling the proliferation of various cell types — including epithelial, endothelial, stromal fibroblasts and immune cells — as well as by influencing the interaction of these cells with the tissue microenvironment. ECM, extracellular matrix; NK, natural killer. Nat Rev Cancer. 2003 Nov;3(11):807-21. * Figure. The role of TGF-? in epithelial carcinogenesis. In normal epithelial cells with an intact TGF-? signaling pathway, TGF-? func