胃癌课件英文Gastric Cancer精选.pptVIP

Conclusions: Despite an increased toxicity, docetaxel based regimens seem to be more efficacious than ECF. In terms of RR and TTP, TCF is the more promising regimen and should be chosen for formal comparison with ECF. This trial is supported in part by Aventis * Multicentric phase II study of epirubicin and docetaxel as first line treatment for patients with advanced gastric cancer: A GERCOR study. Abstract?No:4062:S. Nguyen,Centre Hospitalier de Beauvais, Beauvais, France; Methods: 36 patients (7 females,29 males; performance status [PS] 0/1/2: 12/8/6, LA/M: 7/29; mean weight: 69,6 kg) were treated with epirubicin 60 mg/m2 in 30 minutes, followed 1 h later by docetaxel 75 mg/m2 in 60 minutes, every 21 days, in an outpatient basis . Corticosteroids were administered from day-1 to day 4, and GCSF recommended from day 3 to day 9. All patients were assessable for toxicity (NCI-CTC criteria) and efficacy (Recist evalution criteria). Patients were evaluated every 3 cycles (2 months), and 5FU + platinium-based second-line treatment was recommended at progression * Results: 174 cycles were administered (median 5, range 1-9). No toxic death was reported. Grade 3-4 toxicities were: neutropenia in 41,7% of patients,thrombocytopenia in 5,6%, anemia in 11,1%, nausea-vomiting in 13,9% and diarrhea in 5,6%. Median PS and mean weight remained unchanged at first evaluation. Symptoms (including pain,anorexia and dysphagia ) were improved at first evaluation in one-third of patients with initial symptoms. 1 complete response (CR) (2,7%) and 6 partial response (PR) (16.7%) were obtained , for an overall response (OR) rate of 19,4% (95% CI: 0,07-0,32). 10 patients (27,8%) had stable disease, and 19 patients (52,8%) progressed. Two-third of patients received second-line therapy. With a median follow-up time of 100 weeks, the median PFS and OS times were 18 and 52 weeks , respectively. * Conclusions: First-line efficacy of EPITAX combination is in the same range as that observed in