代谢组学技术在食管癌标志物研究中的应用.pdf

中国细胞生物学学报 Chinese Journal of Cell Biology 2017, 39(2): 238–243 DOI: 10.11844/cj cb.2017.02.02 17 代谢组学技术在食管癌标志物研究中的应用 1 2 1 1 2* 蒋 振 张 欣 王含彦 候 丽 魏 玲 1 ( 川北医学院生物化学教研室, 南充637000; 2 四川大学华西基础医学与法医学院生物化学与分子生物学教研室, 成都61004 1) 摘要 作为一门广泛应用于疾病、肿瘤、营养、药物及微生物等领域的组学技术, 代谢组学 已成为近年来组学技术的研究热点之一。食管癌是严重危害我国居民健康的恶性肿瘤, 运用代谢 组学技术在早期肿瘤标志物的筛选中取得了重要进展。该文对代谢组学与食管癌研究作一综述, 为食管癌防治工作提供参考依据。 关键词 代谢组学; 食管癌; 肿瘤标志物 Advance in Metabolomics Research in Biomarkers of Esophageal Cancer 1 2 1 1 2 * Jiang Zhen , Zhang Xin , Wang Hanyan , Hou Li , Wei Ling 1 2 ( Department of Biochemistry, North Sichuan Medical College, Nangchong 637000, China ; Department of Biochemistry and Molecular Biology, School of Huaxi Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China) Abstract Metabolomics, as a biotechnology widely used in fields such as disease, cancer, nutrition, drugs and microorganism in recent years, has become one of the focuses in “-omics” technology. Esophageal cancer (EC) is a malignance which is extremely harmful to the health of national residents. Metabolomics has made great progress in the screening of biomarkers of EC. This paper reviewed the researches about metabolomics and esophageal cancer in the last two decades to provide a reference basis for treatment and prediction of esophageal cancer. Keywords metabolomics; esophageal cancer; cancer biomarkers 食管癌是严重危害我国居民健康的主要恶性 antigen , SCC-Ag) 、癌胚抗原(carcino-embry