In vivo quantification of intracerebral GABA by single-voxel 1H-MRS—How.pdf

European Journal of Radiology 73 (2010) 526–531 Contents lists available at ScienceDirect European Journal of Radiology j o u rn al h omepage: w w w. elsev /locate/ejr ad In vivo quantification of intracerebral GABA by single-voxel 1H-MRS—How reproducible are the results? W. Bogner a,∗ , S. Gruber a,1, M. Doelken b,2 , A. Stadlbauer c,3 , O. Ganslandt c,4 , U. Boettcher d,4 , S. Trattnig a,5 , A. Doerfler b,6 , H. Stefan e,7 , T. Hammen e,8 a MR Centre of Excellence, Department of Radiology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria b Department of Neuroradiology, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Austria c Department of Neurosurgery, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Austria d Siemens Medical Solution, Karl-Schall Str. 6, D-91052 Erlangen, Germany e Center Epilepsy Erlangen (ZEE), Department of Neurology, University of Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany a r t i c l e i n f o a b s t r a c t Article history: Gamma aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the human brain. It Received 20 August 2008 plays a decisive role in a variety of nervous system disorders, such as anxiety disorders, epilepsy, Received in revised form schizophrenia, insomnia, and many others. The reproducibility of GABA quantification results obtained 23 December 2008 with a single-voxel spectroscopy J-difference editing seque