生活方式和饮食控制对hdl-c影响.pptVIP

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生活方式和饮食控制对hdl-c影响.ppt

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生活方式和饮食控制对hdl-c影响

Lifestyle Changes Lifestyle changes that have a positive impact on high-density lipoprotein cholesterol (HDL-C) levels include weight loss,1 smoking cessation,2 and exercise.3 References: Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr. 1992;56:320–328. Moffatt RJ. Effects of cessation of smoking on serum lipids and high density lipoprotein-cholesterol. Atherosclerosis. 1988;74:85–89. Kokkinos PF, Holland JC, Narayan P, et al. Miles run per week and high-density lipoprotein cholesterol levels in healthy, middle-aged men. Arch Intern Med. 1995;155:415–420. * Weight and HDL-CIn 1988, the National Cholesterol Education Program’s Panel Report identified obesity (i.e., ? 30% overweight) as a factor for clinicians to consider when evaluating cholesterol concentrations and determining treatment. Even mild to moderate excess weight is associated with an increased risk of coronary heart disease. Dattilo and Kris-Etherton conducted a meta-analysis of 70 studies (published between 1966 and 1989) to examine the effects of weight loss by dieting on lipids and lipoproteins. They found a consistent linear association between weight loss and high-density lipoprotein cholesterol (HDL-C) concentrations in both men and women. For every 3 kg (7 lb) of weight loss, HDL-C levels increased 1 mg/dL when weight reduction was maintained. References: Expert Panel. Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Arch Intern Med. 1988;148:36–69. Manson JE, Colditz GA, Stampfer MJ, et al. A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med. 1990;322:882–889. Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr. 1992;56:320–328. * Weight Loss Increases HDL-C Level Wood and colleagues conducted a 1-year random