心力衰竭的信号通路-课件.pptVIP

SD TGR 50 60 70 80 90 100 110 -10 -9 -8,5 -8 -7,5 50 60 70 80 90 100 110 -10 -9 -8,5 -8 -7,5 SD TGR 30 25 20 15 10 5 0 SD TGR AII (pg/g) AI on coronary artery flow Cardiac AII * ACEI 1,6 1,8 2,0 2,2 2,4 2,6 2,8 3,0 LV/B SD-sh SD-ab TGR-ab TGR-sh L V / B ( m g / g ) 0 1 2 3 4 5 6 7 8 ANF Col3 % G A P D H 0 20 40 60 80 100 120 140 160 180 S D - s h T G R - s h S D - a b T G R - a b S D - s h T G R - s h S D - a b T G R - a b ANF Col3 GAPDH SD-sh SD-ab TGR-ab TGR-sh S B P ( m m H g ) * * Age 10 months col1 col3 GAPDH NTGR TGRL1172 TGRL1173 Lisinopril AcSDKP * ACE TGF-β TGF-R1 Smad3 Smad2 Sma