基于适配子的小肝癌诊断分析-diagnosis and analysis of small hepatocellular carcinoma based on aptamer.docxVIP

摘要结论：1．适配子 AP-HCS-9-74 和 AP-HCS-9-132 对小肝癌有良好的诊断价值，尤 其是两者联合分析时。2．小样本分析未能证实 DKK1 和 MDK 的血清水平在小肝癌和肝硬化之间 存在显著差异，单独或两者联合对小肝癌均无明显诊断价值。3．AFP 对小肝癌的诊断价值有限，但与适配子联合分析可明显提高其诊 断价值。关键词：小肝癌；诊断；适配子；DKK1；MDK；AFP；联合分析VABSTRACTBackground and objective:Small primary hepatic carcinoma (sPHC) lacks of obvious symptoms, and serum AFP is mostly negative, therefore, its diagnosis mainly depends on ultrasound B, CT, MRI and/or other imaging techniques. Meta analysis showed that the sensitivities and specificities of these imaging techniques in the diagnosis of all PHC are only 77% ~ 84%, and diagnostic performance is