哮喘的小气道炎症（科内稿）.pptVIP

Nieto A,et al. Montelukast improves pulmonary function measure d by impulse oscillometry in children with asthma (Mio study).Respir Med.2006 Jul;100(7):1180-5. As Xrs5（distal capacitive reactance） reactance has usually negative values, increases are associated with improvement. * Spahn JD,et al. Effect of montelukast on peripheral airflow obstruction in children with asthma. Ann Allergy Asthma Immunol. 2006;96:541-549. 随机双盲，空白对照。21例9-18岁轻中度哮喘儿童，孟鲁司特/安慰剂治疗8周 研究指标：Raw，RV，FEV1 等 随机入组时无论RV还是残气量/肺总量（RV/TLC），孟鲁司特组和安慰剂组的差异都是不显著的。 治疗完成时，使用孟鲁司特治疗组RV和RV/TLC都有显著下降，说明气体闭陷得到明显改善。 * Nakaji H, et al. Eff