raas系统研究的新热点_陈明(英文版）教学文稿.ppt

RAAS系统研究的新热点(The Update Of RAAS Research) ;The hot research of RAAS;Classical circulating RAAS;New expanded view of RAAS;RAAS:from circulation to tissue,then intrcellular ;AT2: New targets of neuronal disease?;AT2 agonist and antagonist;New possible ARBs;Ang II receptors;AT4:an important target for drug development ;ACE2-Ang-(1–7)-Mas axis;ACE2-Ang-(1–7)-Mas axis;Involvement of ACE2 in lung injury;新成员,新靶点,新发现:ACE2 Activator ;ACE2 Activator;Ang-（1-7 ) and Mas agonist ;Chymase :Recognition of Alternative pathways of Ang II generation ;Renin and renin inhibitors;Renin and renin inhibitors:DRIs;Antihypertensive Effects of Aliskiren Compared With Placebo;Renin and renin receptor: independent of A II ;Renin and Renin receptor;RAAS and cardiac arrhythmia ;AngII and Vessel Injure;ARB and Balloon Injure;RAAS and Metabolism of Glucose and Lipids;New study:NAVIGATOR;RAAS and Adipose tissue , obesity;RAAS and Adipose tissue, obesity;?? Aldosterone and Myocardial/Renal Fibrosis;RAAS and renal diseases;After Ontarget:How abou dual blockade of RAAS?;Ongoing study about dual blockade ;Ongoing study about dual blockade;Brain angiotensin II:;Brain angiotensin II;Is the elevation of circulating AngII good for prevention of Stroke?;Is the angiotensin II Type 2 receptor cerebroprotective?;SUMMARY;Thank you