冠心康胶囊治疗冠心病心绞痛心肾亏虚血瘀阻络型的临床分析-clinical analysis of guanxinkang capsule in treating coronary heart disease, angina pectoris, deficiency of heart and kidney, blood stasis and obstruction of collaterals.docx

中文摘要目的：观察冠心康胶囊治疗冠心病心绞痛中医辨证属心肾亏虚血瘀阻络型的临床疗效及其安全性。方法：从四川省中医药科学院中医研究所中医医院心血管门诊、病房及家庭病床中收集60例符合心肾亏虚血瘀阻络型冠心病劳累性稳定型心绞痛患者，采取随机、仿盲、阳性药平行对照设计，分为试验组与对照组2组。试验组口服冠心康胶囊及黄芪注射液静滴，对照组选择地奥心血康胶囊口服及黄芪注射液静滴，疗程口服药为4周，黄芪注射液2周。观察治疗前后各症状记分及相关检查变化情况。结果：本次临床试验结果表明冠心康胶囊对冠心病心绞痛有较好治疗作用，能明显缓解心绞痛及改善心肌缺血，试验组与对照组治疗效果相比有显著差异（P＜0.05）。试验过程中未发生严重不良事件，未发现试验药物各组安全性指标出现与试验药物有关的治疗前后异常或加重的情况。结论：冠心康胶囊治疗冠心病心绞痛中医辨证属心肾亏虚血瘀阻络型的临床疗效肯定，安全可靠。关键词：冠心病劳累性稳定型心绞痛心肾亏虚血瘀阻络冠心康胶囊AbstractObjective：Toinvestigatetheclinicaleffectandsecurityofcapsule“guanxinkang”onstableanginaofcoronaryheartdiseasewithTCMbelongstoheartandkidneydeficiency,superficialvesselsstagnationsyndrome.Methods:60caseofstableanginaofcoronaryarterydiseasewithheartandkidneydeficiency,superficialvesselsstagnationsyndromewereenrolledFromtheclinic,thefamilysickbedandadmissiondepartmentofsichuanProvinceResearchinstituteofTCM.weadoptedparallelcontrolandlistbland design with positive control medical ,and averagely devided intotreatmentgroup1andcontrolgroup.Treatmentgroupweretreatedwithcapsule“guanxinkang”andhuangqiinjection,whilecontrolgroupweretreatedwithcapsule“xinxuekang”andhuangqiinjection.Theperiodofthedistancedrugstakenorallyas4weeks,thehuangqiinjectionfor2weeks. The symptoms and signs were observed both before and aftertreatment. The correlative eximations were taken both before and aftertreatment.Result:TheclinicaltrialexpressedasaresulttheguanxinKangcapsuletotheanginapectorisofcoronaryhavemorecureafunction,canobviouslyalleviateanginapectorisandimproveamyocardialtolackblood,treatmentgroupandcontrolgroupcureeffecttocomparetoshowsignificantdifference(P0.05).Experimentprocessintookplaceseriouslyandbadlyaffairs,haveneverdiscoverexperimentthesafetyindexsignofeachsetofmedicineappearwithexperimentmedicinerelevantoftreatmentinfrontandbackexcrescentoraggravateofcircumstance.Conclusion:GuanxinKangcapsulehascertainclinicaleffectintreatinganginaofcoronaryarterydiseasewithTCMbelongstoheartandkidneydeficiency,superficialvesselsstagnationsyndrome,ithasgoodsafetyduringtre