艾滋病诊治ppt课件.ppt

* * * * * * * * * * * * * Slide #58: The Art of ART: Risk/Benefit Ratio of Antiretroviral Therapy The use of antiretroviral therapy (ART) for HIV infection has led to substantial reductions in morbidity and mortality, and many regimens, such as those combining three or more drugs, result in near-complete suppression of HIV replication. Prolonged use of ART to achieve such benefits has increased our awareness of short- and long-term toxicities that may impact overall health and quality of life beyond that seen with HIV disease. Research continues to refine and develop management approaches that minimize and resolve many toxicities so that long-term benefits with ART can be achieved with uninterrupted therapy. * * * * * * For more information, please see the Capsule Summary at /HIV/Conference%20Coverage/Retroviruses%202006/Capsules/530.aspx * * Les résultats récents de l’étude SMART ont montrer que le risque de certains complications sous laquelles le risque cardiovasculaire est augmenter chez les patients qui arrêtes le traitements pour le VIH et ne recommencent d’être traiter jusqu’à ce que leurs taux de CD4 descends sous 250 cellules. De même l’étude DAD a montrer que la mortalité d?e aux causes cardiovasculaire, illustrée ici avec la ligne jaune, est renforcer chez les patients avec un taux de CD4 de plus en plus baisse. * * * Slide #24: SMART Study: Resumption of HAART Improved Outcomes, but With Residual Effects2008;372:293-299 (see also Lohse N, et al. Ann Intern Med. 2007;146:87-95 and Lewden C, et al. J Acquir Immune Defic Syndr. 2007;46:72-77.) 恢复HAART显著减少了HIV及非HIV事件的发生。但是风险的降低不完全。1 Reference El-Sadr WM, Strategies for Management of Antiretroviral Therapy (SMART) Study Group. Re-initiation of ART in the CD4-guided ART interruption group in the SMART study lowers risk of opportunistic disease or death. Program and abstracts of the 15th Conference on Retroviruses and Opportunistic Infections; February 3-6, 2008; Boston, Massachusetts. Ab