原癌基因Pim-3在胰腺癌发生中的作用机制以及分子靶向治...【精品-ppt】.ppt

原癌基因Pim-3在胰腺癌发生中的作用机制以及分子靶向治疗药物的开发 ;Pim-3激酶在胰腺癌发生中的作用机制 以Pim-3为靶向治疗分子的新型有效的 抗肿瘤药物的开发 ;Pim-3激酶在胰腺癌发生中的作用机制;;Pim-3 is a proto-oncogene with serine/threonine kinase activity.;Normal Tissue;Actin;Pim-1, Pim-2;Pim-3;Pim-3;Actin;小结（1）;以Pim-3为靶向治疗分子的新型有效的抗肿瘤药物开发;;Pim-3与Pim-1具有高度的同源性（70%）和类似的生物功能;合成顺序：T-10 T-6, T-10 T-4 T-5, T-10 T-2 T-3;Pim-3;IC50 (mmol/L);Times after treatment with inhibitor (days); Cell line name ;过表达Pim-3可以部分逆转由T-2引起的细胞活力下降;;T-2抑制Pim-3激酶活性，阻止pBad112, 减少Bcl-XL的表达， 依赖细胞色素C和Caspase-3途径导致细胞凋亡。;5X105 L3.6pl Subcutaneous injection;T-2引起裸鼠皮下胰腺肿瘤细胞凋亡和抑制细胞增殖;T-2 抑制肿瘤新生血管形成; T-2 对裸鼠血清中的一些生化指标没有影响; DMSO T2 (n=5) (n=6);蔓生百部碱可以作为设计Pim-3激酶抑制剂的先导化合物 开发新药，应用临床，为难治性胰腺癌提供新的治疗方法;谢谢！;0oM0oM1pN1pO2qO2qP3rP3sQ4sQ4tR5tR5uS6uS7vT7vT8wU8wV9xV9xWayWazXbzXbAYcAYdBZdBZeC#eC!fD!fD$gE$gF%hF%hGiGjH*jH*kI(kI)lJ)lJ-mK-mL+nL+nM0oM0pN1pN1qO2qO2rP3rP4sQ4sQ5tR5tS6uC#eD!fD!fE$gE$gF%hF%iGiGjH*jH(kI(kI)lJ)lK-mK-mL+nL+oM0oM0pN1pN2qO2qO3rP3rQ4sQ4sR5tR5uS6uS6vT7vT8wU8wU9xV9xWayWayXbzXbAYcAYcBZdBZdC#eC#fD!fD!gE$gE%hF%hFiGiH*jH*jI(kI(lJ)lJ)mK-mK+nL+nL0oM0oN1pN1I(kI(lJ)lJ)mK-mK+nL+nL0oM0oN1pN1pO2qO2rP3rP3sQ4sQ5tR5tR6uS6uT7vT7vU8wU8xV9xV9yWayWbzXbzXcAYcAZdBZdB#eC#eC!fD!fE$gE$gF%hF%iGiGjH*jH(kI(kI)lJ)lK-mK-mL+nL+oM0oM0pN1pN2qO2qO3rP3rQ4sQ4sR5tR5uS6uS#eD!fD!gE$gE$hF%hFiGiG*jH*jI(kI(kJ)lJ)mK-mK-nL+nL0oM0oM1pN1pN2qO2qP3rP3rQ4sQ4tR5tR5uS6uS7vT7vT8wU8wV9xV9xWayWazXbzXbAYcAYdBZdBZeC#eC!fD!fD$gE$gF%hF%hGiGjH*jH*kI(kI)lJ)lJ-mK-mK+nL+nM0oM0H*jH*kI(kI)lJ)lJ-mK-mL+nL+nM0oM0pN1pN1qO2qO2rP3rP4sQ4sQ5tR5tS6uS6uT7vT7wU8wU8xV9xVayWayWbzXbzYcAYcAZdBZdC#eC#eD!fD!gE$gE$hF%hFiGiG*jH*jI(kI(kJ)lJ)mK-mK-nL+nL+oM0oM1pN1pN2qOWayXbzXbAYcAYcBZdBZdC#eC#fD!fD!gE$gE%hF%hFiGiH*5tR5uS6uS6vT7vTqO2qP3rP3rQ4sQ4sR5tR5uS6uS6vT7vT8wU8wU9xV9xWayWayXbzXbAYcAYcBZdBZeC#eC#fD!fD$gE$gE%hF%hGiGiH*jH*kI(kI(lJ)lJ-mK-mK+nL+nM0oM0oN1pN1pO2qO2rP3rP3sQ4sQ5tR5tR6uS6uT7vT7vU8wU8xV9xV9hGiGjH*jH*kI(kI)lJ)lJ-mK-mL+nL+nM0oM0pN1pN1qO2qO3rP3rP4sQ4sR5tR5tS6uS6vT7vT7wU8wU9xV9xVayWa