抑郁症治疗急性期药物选择2017专家版 ppt课件.pptVIP

伤残调整寿命年（disability adjusted life year, DALY）是指从发病到死亡所损失的全部健康寿命年，包括因早死所致的寿命损失年(YLL)和疾病所致伤残引起的健康寿命损失年(YLD)两部分。DALY是生命数量和生命质量以时间为单位的综合度量 物质使用障碍 广泛性发育障碍 变量 早期起效（N=836） 就业状况 早期起效*基线SOFAS评分 基线SOFAS评分 合并其他疾病 基线HDRS17评分 基线HDRS17评分*基线SOFAS评分 早期起效*就业状况 性别 抑郁治疗只有达到临床治愈才能更好的恢复社会功能： 一项研究显示：到达痊愈的患者其社会适应量表评分与健康对照者相似，与未达到治愈的患者相比有显著差异。 A Prospective, Longitudinal Study of the Effect of Remission on Cortical Thickness and Hippocampal Volume in Patients with Treatment-Resistant Depression Methods: FreeSurfer software was used to extract volume or cortical thickness values from 6 regions of interest (hippocampus, rostral middle frontal gyrus, orbitofrontal cortex, rostral and caudal anterior cingulate cortices, and inferior temporal gyrus) in patients (n = 26) and matched healthy controls (n = 28). Regions of interest were selected based on previous evidence of potential associations between morphometric characteristics in these regions and treatment response or remission. Analyses were conducted to compare volume and cortical thickness in patients and controls at baseline imaging, determine whether patients’ brain structure at treatment initiation was associated with response over follow-up, and compare longitudinal changes in volume and cortical thickness in patients who achieved sustained 6-month remission (Montgomery-.sberg Depression Rating Scale Score ≤12) with nonremitters. Results: Patients and controls showed no structural differences at baseline. Among patients, thicker right caudal anterior cingulate cortex at baseline was associated with greater symptom improvement over follow-up. Remitters and nonremitters showed subtle changes in volume and thickness over time in opposing directions, with increased hippocampal volume and cortical thickness in the rostral middle frontal gyrus, orbitofrontal cortex, and inferior temporal gyrus in remitters, and decreased volume or thickness in these regions in nonremitters. Conclusions: The results suggest that longitudinal struct