协调信号通路在上皮的活化和黑色素干细胞使黑色头发再生.docVIP

Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration （协调信号通路在上皮上的活化和黑色素使细胞变色再生） Piul Rabbani,1,2,7 Makoto Takeo,1,2,7 WeiChin Chou,1,2 Peggy Myung,3 Marcus Bosenberg,4 Lynda Chin,5M. Mark Taketo,6 and Mayumi Ito1,2,* 1、Department of Dermatology 2、Department of Cell Biology New York University School of Medicine, New York, NY 10016, USA 3、Department of Dermatology, University Hospitals Case Western Reserve, Cleveland, OH 11100, USA 4、Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA 5、Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA 6、Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8501, Japan 7、These authors contributed equally to this work *Correspondence: mayumi.ito@nyumc.org DOI 10.1016/j.cell.2011.05.004 SUMMARY Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge and secondary hair germ (sHG). Together,they undergo activation and differentiation to regenerate pigmented hair. However, the mechanisms behind this coordinated stem cell behavior have not been elucidated.Here,we identified Wnt signaling as a key pathway that couples the behavior of the two stem cells. EpSCs and McSCs coordinately activate Wnt signaling at the onset of hair follicle regeneration within the sHG. Using genetic mouse models that specifically target either EpSCs or McSCs, we show that Wnt activation in McSCs drives their differentiation into pigment-producing melanocytes,while EpSC Wnt signaling not only dictateshair follicle formation but also regulates McSC proliferation during hair regeneration. Our data define a role for Wnt signaling in the regulation of McSCs and also illustrate a mechanism for regeneration of complex organs through collaboration between heterotypic stem cell populations. 摘要： 黑素细胞干细胞（McSCs）在与毛囊突出和根下毛芽（sHG）处的上皮的干细胞（EpSCs）密切联系，它们一起经历活化和分化成为再生的色素头发。然而，这