重庆医科大学《皮肤性病学》31带状疱疹英文教学课件.ppt

welcome * * Herpes Zoster M.D Zhou xun The First Teaching Hospital of Chongqing University of Medical Sciences Definition Herpes zoster is caused by Varicella - Zoster virus (VZV) , classically occurs unilaterally within the distribution of a sensory nerve, being characterized by clustered vesicles and considerable neuralgia. Pathogen and Pathogenesis Pathogen Varicella-Zoster virus (VZV) is characterized by neurotropism and dermatotropism. Pathogenesis VZV ↓ the primary infection nonimmune host ↓ varicella ↓ VZV establishes latency in sensory ganglia ↓ the decline in immune function VZV may replicate later ↓ Herpes zoster showing neuralgia and clustered vesicles The incidence of herpes zoster increases with advancing age and decline in immune function. Other than immunosuppression and age, the factors involved in reactivation are unknown. Clinical manifestations Prodrome: headache and fever hyperaesthesia pain in the affected area Features of lesions initially presents as papules and plaques of erythema crops of clustered red papules form in a discontinuous band evolve to clear vesicles surrounded by erythema the eruption may have few lesions or reach total confluence in th