【免疫学】-10免疫应答-精品课程下载.pptVIP

Chapter 11. Immune response (1) I. Introduction II. Antibody-mediated Humoral Immunity I. Introduction 1. Concept of Immune Response 2. Types of Immune Response 3. Process of Immune Response 1. Immune response The immune system of body is able to recognize subtle chemical differences that distinguish one foreign pathogen from another. At the same time, the system is able to discriminate between foreign molecules and the body’s own cells and proteins. Once a foreign organism is recognized, the immune system eliminate or neutralize the organism, finally. 2. Types of Immune Response  Autoimmunity selection Immune “Self”Ag Autoimmune ToleranceAg system: activation “non-self”Ag HI / CMI Immune Tolerance  Hypersensitivity Reaction II. Antibody-mediated Humoral Immunity concept of HI ，simple process of HI 1. Common rule of Ab production 2. Interaction between immune cells in process of producing Ab 3. Immune Memory 4. Effect of Humoral Immunity Humoral Immunity，HI Humoral immunity is mediated by antibodies of various different classes; which Ab are produced by cells of the B cell lineage in response to stimulation by Ag. Simple process of HI: 1、TD—Ag APC TH BL2 THm BLm 2、TI—Ag BL1 Mature B cell Plasma cells Ab HI 1.Common rule of Ab production a. The regularity of Ig production in phylogenic evolution and development,and ontogenesis. b. The regularity of Ab production in the primary and seconda