Application of Porous Scavengers for High Throughput ：为高吞吐量应用多孔清除剂.pptVIP

Introduction Solid scavengers are increasingly used in parallel organic synthesis to remove excess reactants or by-products. However, most scavengers are based on gel-type poly- styrene, which features: 1) very high swelling in some solvents - cannot be pre-packed and stored in a cartridge or column format; 2) necessity of swelling - narrow range of compatible solvents. New macroporous scavengers - CombiZorb has been developed based on ultra-pure, spherical silica and low swelling macroporous polystyrene/DVB, to overcome these drawbacks. Macroporous Scavengers Based on ultra-pure, spherical silica: S-Monoamine(NH2), S-Triamine(NH, NH2), S-TertiaryAmine, S-Sulfonic Acid, S-Aldehyde, S-Epoxide, S-Mercaptan, S-Diphenylethylphosphine. Based on low-swelling macroporous polystyrene/DVB: MP-Isocyanate, MP-Aldehyde, MP-Mercaptan, MP-Trisamine(NH, NH2), MP-Piperidinomethyl, MP-Sulfonyl Hydrazide(-NHNH2), MP-Sulfonyl Chloride Features and Advantages (vs. gel-type polystyrene based scavengers) Silica-based: Ultra pure silica - no interference with reactions. Spherical silica - easy to handle, good flow-through properties. No-swelling, high density - larger amount for available volume; possible incorporation into different formats (membrane, column). Porous structure - solvent independent, good mass transfer of reactants. Low-swelling macroporous polystyrene/DVB-based: Low swelling (30% vs. 500% for gels) - larger capacity per vol., easy to handle, possible in different formats (membrane, column). Porous structure - broad solvent compatibility. Performance Comparison