Define Random Heterozygote Advantage, Genetic Drift …：定义了随机杂合子优势，遗传漂变….pptVIP

下载本文档

7
0
约2.39万字
约 15页
2018-06-24 发布于四川
举报
版权申诉

Define Random Heterozygote Advantage, Genetic Drift …：定义了随机杂合子优势，遗传漂变….ppt

1、本文档共15页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Define Random Heterozygote Advantage, Genetic Drift …：定义了随机杂合子优势，遗传漂变…

Define Heterozygote Advantage, Random Genetic Drift and Population Stratification Alison Skinner RCPath Self Help January 22nd 2009 Heterozygote Advantage Heterozygotes have greater relative fitness compared homozygote wildtype and homozygote for the mutation Sometimes referred to as overdominance Maintains genetic variation within a population Most widely known example of this is Sickle cell anaemia, however many other examples exist, including: CFTR GJB2 (CX26) p.C282Y of HFE Phenylketonuria Autoimmune disease susceptibility Sickle Cell Anaemia Caused by the mutation p.E7V of the β-globin gene (HbS) In low oxygen conditions HbS polymerises forming fibrous precipitates HbS homozygotes have crises when the red blood cells sickle, obstructing blood flow to an organ These can cause severe damage and may be fatal. The cell sickles when invaded my the malaria parasite Plasmodium, preventing it from completing its lifecycle HbS homozygotes are resistant to malaria, but are at a fitness disadvantage due to the aforementioned crises HbS heterozygotes (sickle cell trait) generally do not have symptoms (except in extreme situations when they are deprived of oxygen e.g. at high altitude) but are also resistant to malaria Individuals who do not have a copy of HbS are not resistant to malaria Therefore HbS heterozygotes are at an advantage in areas where malaria is prevalent Sickle Cell anaemia Cystic Fibrosis It was postulated that people heterozygous for a CF mutation were at an advantage as they lost less water compared to individuals who did not have a CF mutation when they contracted a diarrhoeal infection This meant they were more likely to survive during the outbreaks of cholera Although individuals who have two CF mutations would be likely to lose even less water, the diagnosis of CF usually resulted in infertility, if the individuals survived to reproductive age (which would have been unlikely before the twentieth century) This theory has been questioned as H?genauer