胃肠细胞非霍奇金淋巴瘤病特征及预后.docVIP

使用前删除此我爱浪漫樱花文档主页： HYPERLINK /mtl168168 /mtl168168，分享文档快乐生活快乐无阻PAGE PAGE 13浅谈【摘要】? 目的： 观察胃肠b细胞性非霍奇金淋巴瘤的临床病理特征，bcl-2、ki-67、cd5的表达和幽门螺杆菌（hp）的感染对其临床病理特征及预后的影响。方法： 收集18例病人的临床病理资料并进行随访，通过he及免疫组织化学染色，观察黏膜相关淋巴瘤及氵弥漫大b细胞淋巴瘤的组织学特点，检测bcl-2、ki-67、cd5及hp，对所得资料进行统计学分析。结果： cd5、ki-67表达及hp感染均随着临床分期的增加而增加。bcl-2阳性组及ki-67表达30%组的淋巴结累及率要高于bcl-2阴性组及ki-67表达≤30%组。cd5阳性组的生存状况要好于阴性组，而ki-67表达30%组及hp感染组生存状况要差于ki-67表达≤30%组及hp未感染组。结论： bcl-2、cd5表达、ki-67高表达及hp感染可能与晚期淋巴瘤有关，bcl-2表达、ki-67高表达可能与淋巴结受累有关，而ki-67表达、hp感染与较差的生存状况相关。 【关键词】? 淋巴瘤，非霍奇金；淋巴瘤，b细胞； 胃肠肿瘤； 基因，bcl-2； ki-67抗原； 抗原，cd5； 预后 ??? ［abstract］ objective: to observe the clinicopathogical features of gastrointestinal b cell lymphomas, expression of bcl-2，cd5, ki-67 and the influence of helicobacter pylori （hp） infection to clinicopathogical features and prognosis of patients. methods: the clinicopathogical data of 18 patients were collected and further follow-up was carried out. the expression of bcl-2, cd5, ki-67 and hp infection were checked by using immunohistochemistry method. all of the data were statistically analyzed. results: the expression of cd5, and ki-67, and hp infection rates increased along with the increasing of the clinical staging of the disease. the rates of lymph node involvement in the groups of bcl-2-positive and ki-67 higher （＞30%） expression （66.67% and 77.78%） were higher than those in groups of bcl-2-negative and ki-67 lower （≤30%） expression （33.33% and 22.22%）. the survival rate of cd5-positive group （100%） was higher than that of cd5-negative group （50%）, while the survival rates in groups of ki-67 higher expression and hp infection-positive （66.67% and 33.33%） were lower than those in groups of ki-67 lower expression and hp infection-negative （100% and 83.33%）. conclusion: the advanced stage of the disease seems accompanied by expression of cd5, higher expression of ki-67 and hp infection. lymph node involvement associates with bcl-2 expression and higher expression of ki-67. lower survival rates associate with high