cxcl12／cxcr4生物学轴诱导前列腺癌骨转移的作用机制研究进展iokqhb.docVIP

CXCL12／CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展现代肿瘤医学2009年8月第17卷第8期?l599?CXCL12/CXCR4生物学轴诱导前列腺癌骨转移的作用机制研究进展杨晨,姚阳AdvanceinfheresearchofthemechanismofCXCL12/CXCR4axisinducedosseousme.tastasisofprostatecancerYANGChen.YAOYangDepartmentofOncology,ShanghaiSixthPeopleHospitalAffiliatedtoShanghaiJiaotongUniversity,Shanghai200233,China.【Abstract】CXCL12(stromal—derivedfactor一1,SDF一1)anditsreceptorCXCR4(chemokine(C—X—Cmotif)receptor4)weredemonstratedtobewidelyexpressedinabroadarrayoftissuesandorgans.RecentstudiessuggestedthatCXCL12/CXCR4axiswasrelatedtotheadhesion,invasion,proliferationandsurvivalofprostatecancercell