04-芳香族化合物A.pptVIP

反应可逆 稀酸加热下可脱去 “保护基团” 磺化 2 R + 或 RCO+ as E+ 生成 ＋R or RCO+ 1 (D) Friedel-Crafts 反应 催化剂用量（烷基化试剂、酰基化试剂） 其它烷基化试剂： 烯烃： 醇： 环氧乙烷： 重排 多取代 Friedel-Crafts reaction 2 Charles Friedel James Mason Crafts Friedel and Crafts had an Accident Charles Friedel and James M. Crafts both observed an unexpected result in Friedels laboratory in 1877. They were trying to prepare amyl iodide by putting iodine and aluminum in the presence of amyl chloride.? Instead of amyl iodide, they got lots of hydrochloric acid and hydrocarbons.? They soon found that aluminum chloride gave the same