膀胱肿瘤卡介苗灌注ppt课件.ppt

乙方有义务提供相应的执业资格证、执业印章等配合甲方工程招投标、承担的工程项目报建及建设施工过程中各类手续办理。 Maintenance Therapy with 3-monthly Bacillus Calmette-Gue′rin for 3 Years is Not Superior to Standard Induction Therapy in High-risk Non–muscle-invasive Urothelial Bladder Carcinoma Ma junhai Lanzhou University Second Hospital Journal Contents Introduction. Patients and methods. Results. Discussion. Limitations. Introduction Patients with high-risk NMIBC are usually treated with adjuvant intravesical instillations of BCG after TUR. The aim is to decrease the risk of recurrence and—to a lesser extent—progression to MIBC. EU guidelines recommend standard induction therapy with once-weekly BCG instillation for 6 wk and at least 1 yr of maintenance therapy with additional instillations of BCG . BCG maintenance therapy for 3 yr following BCG induction can reduce the progression of urothelial bladder carcinoma versus BCG induction alone, but is associated with high toxicity. Patients Patients from the outpatient clinics of the participating centres(18) with high-risk NMIBC were randomised between October 1999 and April 2007 in Spain. methods 1. No maintenance: BCG was instilled once-weekly for 6 wk (a total of 6 instillations). 2. Maintenance: BCG was instilled once-weekly for 6 wk, followed by maintenance therapy with a single instillation every 3 mo for 3 yr (a total of 18 instillations). Results Primary endpoints were disease-free interval (DFI) and time to progression (TTP). Secondary endpoints included survival duration and toxicity. Differences between treatment arms were tested using Student’s t test and x2 and log-rank tests. Results Results Results Results Toxicity : 20 (10%) . Recurrence in 40 (20%). other reasons in 71 (35.5%). (48 received ten or more BCG instillations) 乙方有义务提供相应的执业资格证、执业印章等配合甲方工程招投标、承担的工程项目报建及建设施工过程中各类手续办理。