Tract Tumors JUdoctors泌尿系肿瘤ppt课件.pptxVIP

Urinary Tract Tumors;Renal Cell Carcinoma (RCC);Predisposing factors ;New classification based on the molecular origins of these tumors ;1-Clear Cell Carcinomas;VHL disease ;Those with VHL syndrome inherit a germ-line mutation of the VHL gene on chromosome 3p25 and lose the second allele by somatic mutation. The VHL gene is also involved in the majority of sporadic clear cell carcinomas (60%). homozygous loss of the VHL gene seems to be the common underlying molecular abnormality in both sporadic and familial forms of clear cell carcinomas ;2-Papillary Renal Cell Carcinomas;familial cases: