乳腺癌基因表达的个性化治疗课件.pptVIP

Developing Personalized Therapy Breast Cancer: Gene Expression Signatures;Outcomes of Adjuvant Chemotherapy in Breast Cancer;Objectives;Clinical Case;How else can we classify these tumors?;Sotiriou, C. et al. NEJM, 2009.;Gene Expression Profiles or “Signatures”;The 70-gene Assay: MammaPrint;Mammaprint: Development of the 70-Gene Signature;Retrospective Validation of the 70-Gene Signature;Prognosis Signature Predictive of End Points (10 years);Multivariate Analysis;TRANSBIG Independent Retrospective Validation Study;Does 70-gene Signature have Independent Prognostic Value?;Forrest Plot of HR