Chaper 7 抗原呈递细胞.pptVIP

Antigen processing and presenting Degradation of antigens by one of two pathways yielding antigenic peptides that are displayed bound to MHC molecules on the surface of antigen-presenting cells Different antigen-processing and presentation pathways Endogenous antigens (those generated within the cell) are processed in the cytosolic pathway and presented on the membrane with class I MHC molecules; exogenous antigens (those taken up by endocytosis) are processed in the endocytic pathway and presented on the membrane with class II MHC molecules The cytosolic pathway Peptides for presentation are generated by protease complexes called proteasomes in the cytosol TAP (transporter associated with antigen processing) mediates tranportation of peptides generated in the cytosol into the RER Peptides assemble with class I MHC within RER Class I molecules loaded with peptide exit from the RER, and proceed to the cell surface via the Golgi complex 内源性抗原加工，处理及提呈 The endocytic pathway Peptides are generated from internalized molecules in endocytic vesicles In RER, class II MHC molecules are assembled with the invariant chain (Li) which guides the transportation of class II MHC molecules to endocytic vesicles Peptides assemble with class II MHC molecules by displacing li chain Once a peptide has bound, the peptide-class II complex is transported to the plasma membrane 外源性抗原加工，处理及提呈 Cross-presentation of exogenous antigens In certain cases, APCs may present exogenous antigen to cytotoxic T cells in the context of class I MHC molecules. Presentation of nonpeptide antigens The nonpretein antigens are presented by members of the CD1 family of nonclassical class I molecules 脂类抗原的CD1分子提呈CD1分子： 非经典MHC I类分子 提呈抗原：提呈糖脂或脂类抗原供CD1限制性 T细胞识别 CD1限制性T细胞：CD4-CD8-T; TCRγδT 细胞，NKT细胞等 CD1抗原提呈意义：在机体抗微生物感染和对 脂类抗原的应答中起重要作用 * * Chapter 7 APC Antigen presenting cell (APC) Definition APC is a cell that displays peptide frag