bcl2和ki67蛋白在结肠癌及癌前病变中表达及临床意义.doc

bcl2和ki67蛋白在结肠癌及癌前病变中表达及临床意义 　　【摘要】 目的 检测bcl-2和ki-67在结肠癌及癌前病变中的表达情况，并探讨其临床意义。方法 采用免疫组化方法检测56例结肠癌，38例结肠腺癌，20例正常结肠粘膜，分别进行bcl-2和ki-67蛋白的检测。结果 bcl-2阳性表达率在腺癌与腺瘤中基本相同，阳性表达强度腺癌明显高于腺瘤(P0．01)，腺瘤和腺癌的阳性表达强度及表达率与正常大肠结膜相比差异有显著性(P0．01)。ki-67在腺癌中的表达强度及表达率明显高于腺瘤(P0．01)，有淋巴结转移者明显高于无淋巴结转移者(P0．01)。结论 bcl-2在结肠组织的恶性转化中起着重要作用；ki-67的阳性表达及表达强度对诊断腺癌和监测腺瘤癌变中有重要意义。? 　　【关键词】结肠癌；癌前病变；bcl-2蛋白；ki-67蛋白 　　?? 　　The expression of bcl-2 protein and ki-67 protein in colon cancer and precancerous lesions and Its chinical significance 　　 　　LIU Wei-mei,LIU Jian-min,FENG Lin,et al.Department of Pathology,The Second Jiaozuo People’s Hospital,Henan 454100,China 　　? 　　【Abstract】 Objective Detecting the bcl-2 and ki-67 in the expression of colon cancer and precancerous lesions and and discussing its clinical significance.Methods Testing 56 example colon cancers, 38 example colon adenocarcinoma, 20 example normal colon mucous membrane with immunohistochemistry, and testing bcl-2 and the ki-67 protein separately.Results The rate of bcl-2 positive expression in adenoma and adenocarcinoma is basically the same, the intensity of positive expression of adenocarcinoma is significantly higher than adenomas(P0．01), Compared to the positive expression strength and expression rate of conjunctiva,there are significant difference on adenoma and adenocarcinoma(P0．01).ki-67 in adenocarcinomas expression intensity and expression rate is significantly higher than the rate of adenoma(P0．01), the patients with lymph node metastasis are significantly higher than those non-lymph node metastasis(P0．01).Conclusion bcl-2 play an important role in m alignant transformation of the colon organization; the ki-67 positive expression and the expression intensity has the important meaning to diagnoses in the adenocarcinoma and the monitor adenoma cancer.? 　　【Key words】Colon Cancer;Precancerous lesions;bcl-2 protein；ki-67 protein 　　? 　　结肠癌是消化道常见的恶性肿瘤，发病率有逐年增高的趋势，严重危害人类的健康。结肠癌在不同国家和地区发病率相差悬殊。一般而言，西北欧及北美国家发病率较高，而亚洲、南美洲和非洲国家则较低。我国结肠