CA153CA125CEA联合检测在乳腺癌诊断中临床意义.docVIP

CA153CA125CEA联合检测在乳腺癌诊断中临床意义 　　【摘要】 目的：研究乳腺癌肿瘤标志物CA153、CA125、CEA单独检测和联合检测对于乳腺癌诊断的价值。方法：回顾性分析2014年1月-2017年1月本院收治的女性乳腺疾病患者210例的临床资料。按照术后病理分为乳腺癌组100例和乳腺良性肿瘤组110例，同期选取本院体检健康女性110例为对照组。比较三组CA153、CA125、CEA水平；统计单项及联合检测在乳腺癌诊断中的评价。结果：乳腺癌组CA153、CA125和CEA水平均显著高于乳腺良性肿瘤组和对照组（P0.05）；单独检测时CA153阳性率最高，CA125次之，CEA最低；三项联合检测的灵敏度明显提高，但特异度有所下降。结论：三项肿瘤标志物联合检测对乳腺癌的早期诊断具有临床价值，能够提高早期检出率。 　　【关键词】 乳腺癌； CA153； CA125； CEA 　　Clinical Significance of Combined Detection of CA153，CA125，CEA in the Diagnosis of Mammary Cancer/LUO Dan，CHI Yuemei，WANG Xinchao.//Medical Innovation of China，2018，15（06）：134-137 　　【Abstract】 Objective：To study the value of single and combined detection of tumor marker CA153，CA125，CEA in the diagnosis of mammary cancer.Method：The clinical data of 210 patients with female mammary disease in our hospital from January 2014 to January 2017 were analyzed retrospectively.According to the postoperative pathology，they were divided into 100 cases of mammary cancer group and 110 cases of benign mammary tumor group，and 110 healthy women in the same period were selected as control group.The levels of CA153，CA125 and CEA in three groups were compared，and the evaluation of statistical single item and joint test in the diagnosis of breast cancer.Result：The levels of CA153，CA125 and CEA in mammary cancer group were significantly higher than those of benign mammary tumor group and control group（P0.05）.The positive rate of CA153 was the highest，CA125 was the second，and CEA was the lowest in mammary cancer group.The sensitivity of three joint tests increased significantly，but the specificity decreased.Conclusion：The combined detection of three tumor markers has clinical value in the early diagnosis of mammary cancer，can improve the early detection rate. 　　【Key words】 Mammary cancer； CA153； CA125； CEA 　　First-author’s address：Tianjin 4TH Centre Hospital，Tianjin 300000，China 　　doi：10.3969/j.issn.1674-4985.2018.06.038 　　乳腺癌（breast cancer）?l病率居于女性恶性肿瘤发病率的首位，占女性恶性肿瘤的14.9%[1]，并且发病率呈逐年增高的趋势[