正确认识质子泵抑制剂复习课程.ppt

正确认识质子泵抑制剂（PPIs）;二、质子泵抑制剂作用机制;质子泵抑制剂的分子式;作用机制;*;*;三、主要适应症;四、药物不良反应;;药物不良反应;1.胃肠道感染;2.肺部感染;药物不良反应;五、常用的几种质子泵抑制剂;第一代PPI抑制剂存在的不足和局限性 ;;;总结 ;; As is known to all, all kinds of H+/K+2ATP can play a role by inhibiting the last link of gastric acid secretion in PPIs. The enzyme induced activation is the common characteristics of benzimidazole PPIs, is selectively on the basis of the gastric proton pump, but the role of each PPI and the characteristics of its own. ; On the current clinical application of 4 kinds of PPIs, omeprazole ?has a unique role in inhibiting the H+/K+2ATP enzyme, can completely block any stimulation caused by gastric acid secretion, thereby strong and lasting inhibition of gastric acid secretion. Because of the different structure of lansoprazole, omeprazole has a higher bioavailability. ; Compared with omeprazole and lansoprazole, esomeprazole advantages is weak inhibitory effect on the cytochrome P450, does not affect the metabolism of other drugs in the liver. Rabeprazole also does not have the cytochrome P450 isoenzyme effect, and the interaction with other drugs is less.