子宫内膜腺癌组织中Vasohibin―1与MVD表达及其相关关系研究.docVIP

子宫内膜腺癌组织中Vasohibin―1与MVD表达及其相关关系研究 　　【摘要】 目的：探讨血管生成抑制蛋白-1（Vasohibin-1）、微血管密度（micro vessel density，MVD）在子宫内膜腺癌组织中的表达及两者之间的相关关系。方法：应用SP法检测Vasohibin-1在23例正常子宫内膜组织、28例子宫内膜非典型增生组织及69例子宫内膜腺癌组织中的表达情况；并应用CD34抗体标记上述组织中血管内皮细胞，测定MVD值，分析两者在子宫内膜腺癌的相关关系。结果：Vasohibin-1在子宫内膜腺癌组织中的阳性表达率显著高于子宫内膜不典型增生组织与正常增殖期子宫内膜组织（P0.05）。在子宫内膜腺癌组织中，Vasohibin-1的表达与MVD值呈正相关（r=0.337，P0.05）。结论：在子宫内膜腺癌中存在Vasohibin-1、MVD的高表达，且两者在子宫内膜腺癌的发生、发展中可能起协同作用。 　　【关键词】 子宫内膜腺癌； 血管生成抑制蛋白-1； 微血管密度 　　Research of Expression and Its Correlation of Vasohibin-1 and MVD in Endometrial Adenocarcinoma Tissue/ZHOU Long-shu，HUANG Chan，SHI Wen-jing.//Medical Innovation of China，2016，13（27）：006-009 　　【Abstract】 Objective：To probe the expression of endometrial adenocarcinoma and the relationship between them in angiogenesis inhibitor protein-1（Vasohibin-1） and microvessel density（vessel density micro，MVD）.Method：The expression situation of Vasohibin-1 in 23 cases of normal endometrium，28 cases of atypical endometrial hyperplasia and 69 cases of endometrial adenocarcinoma were detected by SP method.CD34 antibody was used to label the vascular endothelial cells in the tissue，and MVD value was determined.Then，the correlation between endometrial adenocarcinoma between two objects were analyzed.Result：The positive expression rate of Vasohibin-1 in endometrial adenocarcinoma was significantly higher than that in endometrial atypical hyperplasia tissue and normal proliferative phase of endometrial tissue（P0.05）.There was positively correlated in the expression of Vasohibin-1 and the MVD values in the endometrial adenocarcinoma tissue（r=0.337，P0.05）.Conclusion：There is high expression of MVD and Vasohibin-1 in endometrial adenocarcinoma，and they may be played a synergistic role in the occurrence and development of endometrial adenocarcinoma. 　　【Key words】 Endometrial adenocarcinoma； Angiogenesis inhibitor protein-1； Microvessel density 　　First-author’s address：The Second Affiliated Hospital of Guangzhou Medical University，Guangzhou 5