血清TSGF和CA199联合检测对消化道肿瘤诊断意义.docVIP

血清TSGF和CA199联合检测对消化道肿瘤诊断意义 　　【摘要】目的探讨肿瘤指标TSGF和CA199的联合检测对消化道肿瘤诊断的意义。方法临床明确诊断的消化道恶性肿瘤患者80例, 经检查随访排除恶性肿瘤的健康体检者150例作为正常对照组, 进行血清TSGF和CA199检测, 计算并比较两者对消化道恶性肿瘤的诊断效率, 行χ2检验。结果血清TSGF检测的灵敏度、特异性和准确性分别为76.3%、54.0%和61.7%, 血清CA199检测的灵敏度、特异性和准确性分别为58.7%、77.3%和70.9%, 前者的灵敏度高于后者(χ2=6.91, P0.05), 后者的特异性则高于前者(χ2=7.34, P0.05)。结论联合检测血清TSGF和CA199, 可实现优势互补, 显著提高消化道恶性肿瘤的诊断效率。 　　【关键词】肿瘤标记物；消化系统；恶性肿瘤；诊断 　　 　　Diagnostic value#160;of#160;combined detection of serum TSGF and CA199 in m alignant tumor of digestive system WANG Yan-ping,WANG Xi-wen. Department of Nuclear Medicine, Zhucheng People’s Hospital,Zhucheng 262200, China 　　【Abstract】#8195;Objective#8195;To evaluate the diagnostic value of combined detection of serum TSGF and CA199 in m alignant tumor of digestive system. Methods#8195;Choosing 80 patients with definite diagnosis of digestive m alignant tumor, 150 normal persons as control group. Serum TSGF and CA199 were observed and compared by χ2 test. Results#8195;The sensitivity, specificity and accuracy of serum TSGF tests were 76.3%, 54.0% and 61.7%. Those of serum CA199 tests were 58.7%, 77.3% and 70.9%. As to the sensitivity, the former was much higher than the latter(χ2=6.91, P0.05). The specificity of the former was much lower than the latter (χ2=7.34, P0.05). Conclusion#8195;More efficient diagnosis can be made by combined detection of serum TSGF and CA199 for suspected digestive m alignant tumor patients. 　　【Key words】#8195;Tumor labels; Digestive system; M alignant tumor; Diagnosis早期消化道肿瘤可无任何临床症状, 依靠传统的诊断方法难于早期发现和确诊, 使消化道恶性肿瘤成为人类生存的一大杀手［1］。如何早期发现、早期诊断、早期治疗, 成为医疗技术上的重要课题。据文献报道, 肿瘤特异性生长因子(TSGF)是诊断早期肿瘤的一个重要指标, 在消化道肿瘤方面其灵敏度大大高于物理诊断, 但其特异性却并不理想［2］。消化道肿瘤抗原CA199作为消化道恶性肿瘤特异性指标, 其特异性较高, 但灵敏度较差［3］。本研究对80名消化恶性肿瘤患者和150名正常对照同时进行血清TSGF和CA199检测, 旨在提高肿瘤标志物检测对消化道恶性肿瘤的诊断效率。 　　1资料与方法 　　1. 1一般资料80名临床上已明确诊断的消化道恶性肿瘤患者, 其中男46例, 女34例, 平均年龄44.7岁, 年龄(38~61)岁, 包括胃癌25例、结肠癌18例、胰腺癌15例、直肠癌10例、肝细胞癌7例, 胆管癌5例。经检查随访排除恶性肿瘤的健康体检者150例作为正常对照组, 其中男81例, 女69例, 平均年龄51.2岁, 年龄(42~70)岁。 　　1. 2实验方法清晨采用黄色胶头凝胶促凝管