《重症患者与抗生素pkpd的使用》_557复习课程.pptVIP

ICU患者特点 高龄 肾功能不全 低蛋白水平 基础疾病 联合用药 支持治疗，CRRT Luna et al 0 20 40 60 80 100 Ibrahim et al Alvarez-Lerma Rello et al Mortality (%) Garnacho-Montero et al Vallés et al Rello et al. Am J Respir Crit Care Med 1997;156:196–200; Alvarez-Lerma. Intensive Care Med 1996;22:387–394 Ibrahim et al. Chest 2000;118:146–155; Luna et al. Chest 1997;111:676–685 Garnacho-Montero et al. Crit Care Med 2003;31:2742–2751; Vallés et al. Chest 2003;123:1615–1624 Mortality Associated with Appropriate Therapy in Patients with Serious Infections Why do we see continued Mortality? Continuation of terminal process Delay in