董稚明食管鳞癌tgf-β受体基因启动子区甲基化状态研究幻灯片课件.pptVIP

前 言;;DNA 甲基化是在DNA甲基转移酶的作用下,以S-腺苷甲硫氨酸为甲基供体,将甲基基团转移到胞嘧啶第5位碳原子上,从而转变成5-甲基胞嘧啶（5-mC）。;冀医四院; 头颈部鳞癌、胃癌及胰腺癌细胞株中TβRⅠ基因甲基化与其表达降低有关。;研究目的;; 基因; Methylation analysis of TβRⅠand TβRⅡ in tumor tissue (T) and corresponding normal tissues (N). u: indicates the presence of unmethylated genes; m: indicates the presence of methylated genes. Cases 1: tumor-specific methylation; Case 2: the tumor is fully methylated, whereas the corresponding normal tissue has a very faint band demonstrating methylation; Case 3: both of tumor and corresponding normal tissue unmethylated.;Unmethy