2013—2017年中山陈星海医院妇科病原菌分布和其耐药.PDF

·2138 · 现代药物与临床 Drugs Clinic 第 33 卷 第 8 期 2018 年 8 月 2013—2017 年中山市陈星海医院妇科病原菌的分布及其耐药性分析 黄超妹，李 静 中山市陈星海医院 妇科，广东 中山 528415 摘 要：目的 探讨 2013—2017 年中山市陈星海医院妇科病原菌的分布及其耐药性，旨在为临床预防及诊治提供相应的经 验。方法 收集 2013—2017 年中山市陈星海医院妇科病房收治的发生住院感染的 562 例患者的临床资料，对其感染病原菌 的分布及耐药性进行分析。结果 共分离出病原菌 1 048 株，标本来源以宫颈分泌物为主，占 52.86% 。感染部位主要发生 在宫颈和腹部切口，构成比分别为 26.81% 、25.00% 。革兰阴性菌615 株，构成比为 58.68%，主要为大肠埃希菌、铜绿假单 胞菌、肺炎克雷伯菌、沙雷菌属和鲍曼不动杆菌；革兰阳性菌 288 株，构成比为 27.48% ，主要为金黄色葡萄球菌和表皮葡 萄球菌；真菌 145 株，构成比为 13.84%，主要为白色假丝酵母和热带假丝酵母菌。革兰阳性菌中表皮葡萄球菌对头孢曲松、 庆大霉素和头孢哌酮舒巴坦的耐药性较高，耐药率均在 80% 以上。金黄色葡萄球菌对亚胺培南和阿奇霉素的敏感率较高。 革兰阴性菌中大肠埃希菌和铜绿假单胞菌对阿米卡星和亚胺培南具有较高的耐药性，耐药率均高达 85% 以上；肺炎克雷伯 菌对庆大霉素、亚胺培南和阿奇霉素的耐药率均为 0 。结论 2013—2017 年中山市陈星海医院妇科病原菌分布较为广泛，在 临床中应结合药物的耐药性合理使用抗菌药物。 关键词：病原菌；耐药性；抗菌药物 中图分类号：R978.1 文献标志码：A 文章编号：1674 - 5515(2018)08 - 2138 - 04 DOI: 10.7501/j.issn.1674-5515.2018.08.061 Analysis on distribution and drug resistance of gynecological pathogens in Chenxinghai Hospital of Zhongshan City from 2013 to 2017 HUANG Chao-mei, LI Jing Department of Gynecology, Chenxinghai Hospital of Zhongshan City, Zhongshan 528415, China Abstract: Objective To explore the distribution and drug resistance of gynecological pathogens in Chenxinghai Hospital of Zhongshan City from 2013 to 2017, and to provide corresponding experience for clinical prevention and treatment. Methods The clinical data of patients (562 cases) with hospital infection in the gynecological ward of Chenxinghai Hospital of Zhongshan City from 2013 to 2017 were enrolled. The pathogen distribution and drug resistance were analyzed. Results There were 1 048 strains of pathogens identified. The specimens were mainly from cervical secretions, accounting for 52.86%. The most infection sites were cervical and abdominal incisions, accounting for 26.81% and 25.00%, respectively. There were 615 strains