纤支镜治疗支气管扩张并感染临床的研究.docVIP

纤支镜治疗支气管扩张并感染临床的研究 　　doi：10.3969/j.issn.1007-614x.2014.22.11 　　摘要目的：研究支气管镜下灌洗治疗支气管扩张并感染的临床疗效。方法：2012年5月-2013年7月收治气管扩张并感染患者80例，随机分成观察组和对照组，每组40例。对照组采用祛痰、补液、抗感染、纠正水电解质平衡等治疗；观察组在对照组的基础上加用纤支镜下局部灌洗。2周1个疗程，观察两组抗生素用药时间、临床症状及血清CRP（C-反应蛋白）值。结果：观察组痊愈率（13/40）和总有效率（37/40）均高于对照组（9/40）和（27/40），两组差异具有统计学意义（P0.05）。观察组抗生素用药天数（10.35±4.56）天明显少于对照组（17.30±5.10）天，差异具有统计学意义（P0.01）。两组治疗后血清CRP值明显降低，差异具有统计学意义（P0.01）。结论：纤支镜治疗支气管扩张并感染能够有效缩短抗生素疗程，减轻患者炎性反应，安全有效，值得在临床上推广应用。 　　关键词支气管扩张；感染；支气管镜；疗效 　　Clinical research of bronchoscopy in the treatment of bronchiectasis combined with infection 　　Ma Xiaozhong 　　Department of Respiration，the People’s Hospital of Linxia State，Gansu 731100 　　AbstractObjective：To study the clinical effect of the bronchoscopy lavage in the treatment of bronchiectasis combined with infection.Methods：80 bronchiectasis patients with infection were selected from May 2012 to July 2013.They were randomly divided into the observation group and the control group with 40 cases in each.The control group were treated with expectorant， fluid infusion，anti infection，correcting water and electrolyte balance treatment.The observation group were treated with bronchoscopy microscopic local lavage on the basis of the control group.Two weeks were one course of treatment.The medication times of antibiotic，clinical symptoms and serum CRP（C-reactive protein） values of patients in two groups were observed.Results： The cure rate（13/40） and the total effective rate（37/40） of the observation group were higher than （9/40） and （27/40） of the control group.The difference between the curative effects of patients in two groups was statistically significant（P0.05）.The medication days of antibiotic in the observation group was （10.35±4.56） days，and it was significantly less than （17.30±5.10） days of the control group.The difference was statistically significant（P0.01）.After treatment，the serum CRP levels of patients in two groups were decreased significantly，and the difference was statistically sig