口腔微生物与消化系统疾病关系的研究进展.PDFVIP

36 3 2018 6 华西口腔医学杂志 第 卷 第 期 年 月   West China Journal of Stomatology Vol.36 No.3 Jun. 2018 •331 • 口腔微生物与消化系统疾病关系的研究进展 李博磊 程磊 周学东 彭显 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心 四川大学华西口腔医院牙体牙髓病科，成都610041 [摘要] 人类微生物组计划使人们对口腔微生物的认识更加深入。口腔微生物不仅在龋病、牙周病、口腔癌等口腔 疾病的病程中发挥重要作用，还与其他全身系统疾病关系密切。口腔微生物与消化系统疾病间存在紧密的相关性， 可以促进结直肠癌的发生和发展。本文对口腔微生物与消化系统疾病的研究进展、口腔微生物在消化系统疾病进程 中的重要作用以及口腔微生物作用于消化系统多脏器的途径进行综述，为口腔微生物与全身系统疾病的进一步研究 提供参考。 [关键词] 口腔微生物； 口腔菌群； 消化系统疾病； 微生物组 [中图分类号] R 780.2 [文献标志码] A [doi] 10.7518/hxkq.2018.03.019 Research progress on the relationship between oral microbes and digestive system diseases Li Bolei, Cheng Lei, Zhou Xuedong, Peng Xian. (State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China) Supported by: The National Natural Science Foundation of China . Correspondence: Peng Xian, E-mail: pengx @. [Abstract] The human microbiome project promoted further understanding on human oral microbes. Besides oral diseases such as dental caries, periodontal disease, and oral cancer, oral microbes are closely associated with systematic diseases. They have a close connection with digestive system diseases and even contribute to the origination and progression of colorectal cancer. By reviewing recent studies involving oral microbe-related digestive systemic diseases, we aim to propose the con- siderable role of oral microbes in relation to digestive systemic diseases and the way of oral microbes to multiple