痛风発作後-长瀬クリニック.PPT

* * * * * * * * * * * * * * Pathways of urate Alexander So, Bernard Thorens J Clin Invest. 2010;120(6):1791-1799 Cytokine and chemokines that play a role in gouty inflammation Busso and So Arthritis Research Therapy 2010 12:206 IL-1β Endothelial adhesion Monocyte, dendritic cells inflammatory macrophage Endogenous pyrogen TNFα Cellular activation Monocyte, macrophage, lining cell Endothelial adhesion Phagocytosis IL-6 ? Monocyte, macrophage Granulocyte colony-stimulating factor Neutrophil survival and proliferation Endothelium, macrophage CXCL1 (KC, Groa) Neutrophil chemotaxis Ma